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干细胞/祖细胞
Vismodegib (GDC-0449)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
V127477-10mg | 879085-55-9 | 询价 |
V127477-500mg | 879085-55-9 | 询价 |
V127477-1g | 879085-55-9 | 询价 |
V127477-250mg | 879085-55-9 | 询价 |
V127477-100mg | 879085-55-9 | 询价 |
V127477-50mg | 879085-55-9 | 询价 |
产品介绍
- 分子式 C19H14Cl2N2O3S
- 分子量421.31
属性
熔点 | 168-180 °C |
溶解性 | Soluble in DMSO (200 mg/ml), ethanol (10 mg/ml), and water (very poorly, maximum solubility in plain water is estimated to be about 10-20 μM buffers, serum, or other additives may increase or decrease the aqueous solubility). |
存贮条件 | 储存温度-20°C |
描述
应用 | A potent hedgehog (Hh) signaling pathway inhibitor. |
产品介绍 | Vismodegib (GDC-0449)是一种有效的,新型的,特异性的hedgehog抑制剂,IC50为3 nM。GDC-0449也抑制P-gp作用,IC50为3.0μM。 |
备注 | Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM. |
生化机理 | Vismodegib is a potent hedgehog (Hh) signaling pathway inhibitor. Vismodegib is a potent inhibitor of two ABC transporters, ABCG2 and ABCB1/Mdr-1, with IC50 values of 1.4 and 3.0 μM, respectively. Vismodegib may have antitumor activity in locally advanced or metastatic basal-cell carcinoma. |
别名 | GDC-0449; GDC 0449; GDC0449;2-氯-N-[4-氯-3-(2-吡啶基)苯基]-4-(甲磺酰基)苯甲酰胺;GDC-0449;GDC 0449;GDC0449;HhAntag691; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide |
Vismodegib (GDC-0449)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Vismodegib (GDC-0449)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途