诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞信号转导
GF109203X
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| G129390-1mg | 133052-90-1 | 询价 |
| G129390-50mg | 133052-90-1 | 询价 |
| G129390-10mg | 133052-90-1 | 询价 |
产品介绍
- 分子式 C25H24N4O2
- 分子量412.48
- Beilstein号
- EC号
- MDL号 MFCD00236428
- PubChem编号
属性
| 溶解性 | Soluble in DMSO (~1 mg/ml), DMF (10 mg/ml; warm to 40°C & vortex well), and 1:10 DMSO:PBS (pH 7.2) (~0.1 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | A highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3 |
| 产品介绍 | GF109203X是一种有效的PKC抑制剂，抑制PKCα， PKCβI， PKCβII和PKCγ，IC50分别为20 nM， 17 nM， 16nM和20 nM，作用于PKC比作用于EGFR， PDGFR和胰岛素受体选择性高3000倍以上。 |
| 备注 | GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
| 生化机理 | Bisindolylmaleimide I (GF 109203X) is a staurosporine inspired molecule, which has been shown to display equally potent inhibition, but with vastly superior selectivity, for all of the known isoforms of PKC (IC50 = 8-20 nM). Inhibition is competitive with respect to ATP, which suggests that Bisindolylmaleimide I occupies the ATP binding domain of the PKC isoforms. Bisindolylmaleimide I (GF 109203X) has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It inhibits PKC within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases, as well as GSK-3. |
| 别名 | 3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮;;双吲哚马来酰亚胺 I;Bisindolylmaleimide I;3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-Pyrrole-2,5-dione, |
GF109203X信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于GF109203X报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途