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Pirfenidone
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P129335-100mg | 53179-13-8 | 询价 |
| P129335-5g | 53179-13-8 | 询价 |
| P129335-1g | 53179-13-8 | 询价 |
| P129335-250mg | 53179-13-8 | 询价 |
产品介绍
- 分子式 C12H11NO
- 分子量185.22
- Beilstein号 21(5)7,197
- EC号
- MDL号 MFCD00866047
- PubChem编号
属性
| 溶解性 | Soluble in water (>10 mg/ml at 60 °C), chloroform, DMSO (>20 mg/ml), ethanol, and DMF. |
描述
| 应用 | An antifibrotic and antioxidant small molecule |
| 产品介绍 | Pirfenidone is a small molecule antifibrotic agent. In pulmonary fibrosis studies, Pirfenidone is shown to block collagen production and mitigate the presentation of bleomycin- and cyclophosphamide-induced fibrosis. This intervention appears in part on the transcriptional level, with Pirfenidone exposure correlating to a significant decrease in levels of procollagen I and III gene-assoicated messenger RNA. The antioxidant radical-scavenging activity additionally demonstrated by Pirfenidone suggests a role in protecting against lipid peroxidation, and may attribute to the antifibrotic property of the compound. |
| 备注 | Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Phase 3. |
| 生化机理 | Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials. |
| 别名 | 5-甲基-1-苯基-2-(1H)-吡啶酮;吡非尼酮;5-Methyl-1-phenyl-2-pyridone; 5-Methyl-1-phenyl-2-(1H)-pyridone |
Pirfenidone信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Pirfenidone报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途