诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
抗生素
格尔德霉素
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| G102383-10mg | 30562-34-6 | 询价 |
| G102383-250mg | 30562-34-6 | 询价 |
| G102383-50mg | 30562-34-6 | 询价 |
产品介绍
- 分子式 C29H40N2O9
- 分子量560.64
- Beilstein号
- EC号
- MDL号 MFCD00274570
- PubChem编号
属性
| 熔点 | 255°C |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in dimethyl sulfoxide at 100 mg/mL. |
| 存贮条件 | 储存温度:-20℃ |
| 密度 | 1.2300 |
描述
| 产品介绍 | λmax 305(MeOH)(Lit.) A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Geldanamycin has antiproliferative and antitumor effects. Rapidly depletes p185c-erbB2 protein tyrosine kinase in breast carcinoma cells. Binds to HSP90 and disrupts Raf1-HSP90 complex leading to destabilization of Raf1. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase activity. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines. A benzoquinoid antibiotic that is a potent inhibitor of pp60src tyrosine kinase. Geldanamycin has antiproliferative and antitumor effects. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal Kinase activity. Binds to HSP90 and disrupts raf1-HSP90 complex leading to destabilizing of Raf1. Also destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits c-myc expression in murine lymphoblastoma cells. Approximately ten-fold more potent than herbimycin A |
| 生化机理 | 格尔德霉素是一种强效的抗肿瘤抗生素。在纳摩尔浓度级对60个细胞系具有活性。特异性结合热休克蛋白Hsp90和它的内质网同源物GP96，从而干扰了蛋白质的构象和细胞应激反应。此外，它是一种强效的核激素受体家族抑制剂。 |
| 别名 | 格尔德霉素;Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem；NSC 122750 U-29135 |
格尔德霉素信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于格尔德霉素报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途