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抗生素

Dexamethasone

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
D137736-1g 50-02-2 询价
D137736-25g 50-02-2 询价
D137736-5g 50-02-2 询价
产品介绍

属性

熔点 262-264°C
敏感性 对光线和空气敏感
溶解性 Soluble in ethanol (25 mg/ml), and DMSO (25 mg/ml). Insoluble in water.

描述

应用 Dexamethasone has been used:
· in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue
· as a component of adipocyte differentiation medium
· for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)
产品介绍 Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
生化机理 Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. Dexamethasone is an activator of IDO.
别名 21α-乙酰氧基-9α-氟-11β;17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮;9α-氟-16α-甲基氢化泼尼松;9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮;德沙美松;氟美松;(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途