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抗生素
普卡酶素
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P113149-1mg | 18378-89-7 | 询价 |
| P113149-25mg | 18378-89-7 | 询价 |
| P113149-5mg | 18378-89-7 | 询价 |
产品介绍
- 分子式 C52H76O24
- 分子量1085.15
- Beilstein号 5236667
- EC号 MFCD00135618
- MDL号 MFCD00135618
- PubChem编号 24897127
属性
| 熔点 | 170-175°C |
| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water. |
| 存贮条件 | 储存温度-20°C ，充氩保存 |
| 密度 | 1.4800 |
描述
| 应用 |
A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA;DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium; Used as an antineoplastic agent |
| 产品介绍 | Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells |
| 生化机理 | Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes. |
| 别名 | 普卡酶素 ;光辉酶素;光神霉素;普芳拉星;金霉酸;Mithramycin A;Mithramycin;Aureolic acid;Mithramycin A |
普卡酶素信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于普卡酶素报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途