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抗生素
多球壳菌素
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M102400-1mg | 35891-70-4 | 询价 |
| M102400-25mg | 35891-70-4 | 询价 |
| M102400-5mg | 35891-70-4 | 询价 |
产品介绍
- 分子式 C21H39NO6
- 分子量401.54
- Beilstein号
- EC号 MFCD01632772
- MDL号 MFCD01632772
- PubChem编号 24896622
属性
| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.1230 |
描述
| 应用 | An inhibitor of sphingolipid biosynthesis with immunosuppressive properties. |
| 产品介绍 | Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model. |
| 生化机理 | Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. |
| 别名 | Myriocin;嗜热菌杀酵母素;ISP-1;2S,3R,4R,6E-2-氨基-3,4-二羟基-2-羟甲基L-14-氧-6-二十烯酸;(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; ISP-I; Thermozymocidin |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途