诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
糖类
Trehalose 6,6′-dimycolate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T120976-1mg | 61512-20-7 | 询价 |
产品介绍
- 分子式 C172O15H328
- 分子量2,636.47
- Beilstein号
- EC号
- MDL号 MFCD00081533
- PubChem编号
属性
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A glycolipid that induces macrophages to release inflammatory cytokines independent of TLR2 or TLR4 |
| 产品介绍 | To stimulate mouse bone marrow-derived macrophages, Cord Factor was suspended at a concentration of 0.2mg/ml in hexane. Of the resulting solution 1 or 10μg/well were layered in 96-well tissue culture plates and the solvent completely evaporated. Control wells were layered with solvent without Cord Factor and also incubated at 37°C. To this layer of Cord Factor, bone marrow-derived macrophages were added in 100μl of medium and incubated at 37°C for 24 hours before activation e.g. TNF-α production was measured in the supernatant. In vivo pulmonary granuloma formation in mice can be induced by 10μg Cord Factor per mouse applied i.v. in a water/oil/water emulsion. |
| 生化机理 | Cord factor is a glycolipid released from Mycobacterium that becomes toxic and antigenic when it interacts with cell surface lipids. It activates macrophages to release inflammatory cytokines and induces thymic atrophy and granuloma formation in lung and other organs. It is responsible for the necrosis and cavitation observed in secondary tuberculosis. |
| 别名 | Cord Factor;Cord Factor |
Trehalose 6,6′-dimycolate信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Trehalose 6,6′-dimycolate报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途