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荧光试剂
Dansylcadaverine
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| D131032-1g | 10121-91-2 | 询价 |
| D131032-250mg | 10121-91-2 | 询价 |
| D131032-50mg | 10121-91-2 | 询价 |
产品介绍
- 分子式 C17H25N3O2S
- 分子量335.46400
- Beilstein号 2951070
- EC号 233-326-9
- MDL号 MFCD00042704
- PubChem编号 24893805
属性
| 敏感性 | 对空气敏感 |
| 溶解性 | 10 mg/mL Methanol |
| 存贮条件 | 储存温度-20°C 充氩保存 |
描述
| 应用 |
A fluorescent amine probe Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used: · as an endocytosis inhibitor in human proximal tubular HK-2 cells, mouse J774A.1 macrophages and human A549 epithelial cells · to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies · in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples |
| 产品介绍 | Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. Dansylcadaverine functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. It is known that the specificity of Dansylcadaverine towards mammalian autophagosomes is due to ion trapping through the acidic compartments of autophagosomes. In addition, Dansylcadaverine has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination, and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles, which requires a brief exposure to the compound compared to previous methods. |
| 生化机理 | 自发荧光染料丹酰尸胺或单丹磺酰尸胺（MDC）通常用于监测自噬。 由于离子捕获和与膜脂质的特异性相互作用的组合，单丹磺酰尸胺优先在自噬泡中积累。 |
| 别名 | 丹酰尸胺;N-丹酰-1,5-戊二胺;N-(5-氨基戊基)-5-(二甲基氨基)萘-1-磺酰胺;N-(5-Amino-pentyl)-5-di-methyl-amino-naphtha-lene-1-sulfon-amide; N-(Dimethyl-amino-naphtha-lene-sulfonyl)-1,5-pentane-diamine Monodansyl cadaverine |
Dansylcadaverine信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Dansylcadaverine报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途