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6,7-二甲氧基香豆素

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
D101246-1g 120-08-1 询价
D101246-250mg 120-08-1 询价
D101246-25g 120-08-1 询价
D101246-5g 120-08-1 询价
产品介绍

属性

熔点 143-145°C
溶解性 Soluble in DMSO (15 mg/ml), and water (partly miscible).
密度 1.2480

描述

应用 An agent that can up-regulate the expression and activate CAR
产品介绍 Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
别名 蒿属香豆素;Scoparone;6,7-Dimethylesculetin;6,7-Dimethoxy-2H-chromen-2-one;6,7-Dimethoxy-2-benzopyrone

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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途