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脂类
cholest-(25R)-5-ene-3β,27-diol
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| C130177-5mg | 20380-11-4 | 询价 |
| C130177-25mg | 20380-11-4 | 询价 |
产品介绍
- 分子式 C27H46O2
- 分子量402.65300
属性
| 溶解性 | Soluble in chloroform. Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | An oxysterol with cholesterol oxidation metabolite properties. |
| 产品介绍 | 27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells in vitro. 27-Hydroxycholesterol has also been reported to increase levels of Aβ peptide production, reduce mitochondrial membrane potential, and induce nuclear factor κB (NFκB) and heme-oxygenase 1 (HO-1). Overall, 27-Hydroxycholesterol displays apoptotic properties via reactive oxygen species (ROS) generation, glutathione depletion, and inflammation. 27-Hydroxycholesterol is an activator of LXR α and LXR β. |
| 别名 | 27-羟基胆固醇;5,25R-胆甾烯-3beta,26-二醇；;27-hydroxycholesterol;5,25R-Cholesten-3beta,26-diol;cholest-5-ene-3β,27-diol, (25R);27-hydroxycholesterol(25R);(25R)-Cholest-5-ene-3β,26-diol |
cholest-(25R)-5-ene-3β,27-diol信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于cholest-(25R)-5-ene-3β,27-diol报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途