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2',3'-二脱氧胞苷
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| D119514-1g | 7481-89-2 | 询价 |
| D119514-250mg | 7481-89-2 | 询价 |
| D119514-50mg | 7481-89-2 | 询价 |
- 分子式 C9H13N3O3
- 分子量211.22
- Beilstein号 654956
- EC号
- MDL号 MFCD00012188
- PubChem编号 24278377
属性
| 熔点 | 209°C |
| 旋光率 | +75.0 to +80.0°(C=1, H2O) |
| 溶解性 | Soluble in water (76.4 mg/ml at 25°C), DMSO (42 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | 2',3'-二脱氧胞苷 ;2,3-二脱氧胞嘧啶核苷 2',3'-二脱氧胞甙 双脱氧胞嘧啶核苷 2',3-双脱氧胞嘧啶核苷 扎西胞苷扎西他滨 ;2′,3′-Dideoxycytidine ;7481-89-2; C9H13N3O3 |
| 生化机理 |
Zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NARTI). Zalcitabine is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Zalcitabine is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite works as a substrate for HIV reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. Since Zalcitabine is a reverse transcriptase inhibitor it possess activity only against retroviruses. |
| 别名 | 2,3-二脱氧胞嘧啶核苷 ,2',3'-二脱氧胞甙 ,双脱氧胞嘧啶核苷 ,2',3-双脱氧胞嘧啶核苷 ,扎西胞苷,扎西他滨 ;ddC,1-(2,3-Dideoxy-β-D-ribofuranosyl)cytosine,Zalcitabine |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途