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阿戈美拉汀
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| A124691-1g | 138112-76-2 | 询底价 |
| A124691-250mg | 138112-76-2 | 询底价 |
| A124691-25g | 138112-76-2 | 询底价 |
| A124691-25mg | 138112-76-2 | 询底价 |
| A124691-50mg | 138112-76-2 | 询底价 |
| A124691-5g | 138112-76-2 | 询底价 |
| A124691-5mg | 138112-76-2 | 询底价 |
- 分子式 C15H17NO2
- 分子量243.30
- Beilstein号
- EC号 MFCD00916659
- MDL号 MFCD00916659
- PubChem编号
属性
| 存贮条件 | 储存温度 2-8°C |
描述
| 产品介绍 | Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. It is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties. In neurogenesis assays, both in vitro and in vivo, the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C, demonstrating actions through all three receptors. |
| 生化机理 |
Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. Agomelatine is an antidepressant drug. |
| 别名 | N-[2-(7-甲氧基-1-萘基)乙基]乙酰胺;S-20098;N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途