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Letrozole
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| L129473-100mg | 112809-51-5 | 询价 |
| L129473-1g | 112809-51-5 | 询价 |
| L129473-25mg | 112809-51-5 | 询价 |
| L129473-500mg | 112809-51-5 | 询价 |
| L129473-5g | 112809-51-5 | 询价 |
产品介绍
- 分子式 C17H11N5
- 分子量285.30300
- Beilstein号
- EC号
- MDL号 MFCD00866241
- PubChem编号
属性
| 存贮条件 | 储存温度-20°C |
描述
| 应用 |
Letrozole has been used: · in organoid growth assay to determine its inhibitory capacity(48) · to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49) · to determine its effects on tumor-induced hyperalgesia(50) · for hormonal manipulation in rats(51) · to study its effects on lipocalin-2 (Lcn2)(52) · to determine its effects on mechanical hyperalgesia and aromatase expression(53) |
| 产品介绍 | Letrozole是非甾体类芳香酶抑制剂，其 IC50 为1-13 nM；是第三代aromatase抑制剂，无细胞试验中IC50为0.07-20 nM。在临床研究中，对17α-OH progesterone、TSH、促黄体激素、促卵泡激素或雄烯二酮的血浆浓度没有作用，不影响正常的尿电解质排泄或甲状腺功能。 |
| 生化机理 | Letrozole acts as an adjuvant agent and is used to treat breast cancer. Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. |
| 别名 | 来曲唑 ;Femara, Piroxicam； 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile |
Letrozole信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Letrozole报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途