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内皮素-1
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| E101621-5mg | 117399-94-7 | 询价 |
| E101621-1mg | 117399-94-7 | 询价 |
产品介绍
- 分子式 C109H159N25O32S5
- 分子量2491.90
- MDL号 MFCD00133305
- PubChem编号 24894656
属性
| 存贮条件 | 储存温度 -20°C |
| 密度 | 1.1300 |
描述
| 应用 |
带有人类和猪内皮素1序列的合成肽。生物来源是带有相同序列的人内皮素 ETA 和 ETB内皮素受体强效激动剂。诱导缺氧诱导因子1α血管内皮生长因子的生产。 |
| 产品介绍 | Amino Acid Sequence:Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp [Disulfide Bridges: 1-15; 3-11]. Endothelin-1 (ET-1) is synthesized and secreted by activated endothelial cells, and is a peptide with potent vasoconstrictor activity. It is a marker for activated or dysfunctional endothelial cells. This peptide is one of the three isopeptides belonging to the endothelin family. It is also released by cardiomyocytes. |
| 生化机理 |
Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions. ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells. The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects. The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests. Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF. |
| 别名 | ;ET-1 H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH |
内皮素-1信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于内皮素-1报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途