诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞信号转导
Wortmannin
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| W100984-5mg | 19545-26-7 | 询价 |
| W100984-10mg | 19545-26-7 | 询价 |
| W100984-25mg | 19545-26-7 | 询价 |
产品介绍
- 分子式 C23H24O8
- 分子量428.43
- Beilstein号 67676
- MDL号 MFCD00133927
- PubChem编号 24278777
属性
| 敏感性 | 对热、湿度和光线敏感 |
| 溶解性 | Soluble in DMSO (50 mg/ml), ethanol (25 mg/ml), methanol, 1:8 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~14 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3900 |
描述
| 应用 | A fungal metabolite which inhibits Pl3-kinase |
| 产品介绍 | Wortmannin是一种PI3K抑制剂，IC50为3 nM，抑制自噬体的形成，也有效抑制DNA-PK/ATM，IC50分别为16 nM和150 nM。 |
| 生化机理 | Wortmannin, a fungal metabolite, is a potent and selective inhibitor of PI 3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin displays a similar potency in vitro for the class I, II, and III PI 3-kinase members, although it can also inhibit other PI 3-kinase-related enzymes such as FRAP (mTOR), DNA-PKCS, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI 3-kinase. The half-life of Wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI 3-kinase. Wortmannin is an inhibitor of Fnk and Plk |
| 别名 | KY 12420;抗生素SL-2052;KY 12420;Antibiotic SL-2052 |
Wortmannin信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Wortmannin报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途