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奥沙利铂
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
AI问答
配套的仪器设备？
可以搭配的相关耗材试剂？
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| O124003-100mg | 61825-94-3 | 询底价 |
| O124003-25mg | 61825-94-3 | 询底价 |
| O124003-500mg | 61825-94-3 | 询底价 |
产品介绍
- 分子式 C8H14N2O4Pt
- 分子量397.29
- Beilstein号
- EC号
- MDL号 MFCD00866327
- PubChem编号
属性
| 敏感性 | 热敏感 |
| 溶解性 | Soluble in water with heating and/or sonication |
| 存贮条件 | 储存温度 2-8°C； 充氩保存 |
描述
| 应用 | A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines |
| 产品介绍 | Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin , the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin or Carboplatin , and shows antitumor activity in cell lines with acquired Cisplatin resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently. |
| 生化机理 |
Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin forms platinum-DNA adducts. Oxaliplatin causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. |
| 别名 | (反-1,2-环己烷二胺)草酸铂(II)；奥利沙铂；[SP-4-2-（1R-反式）] -（1，2-环己二胺-N，N′）[乙二酸（2-）-O，O’]铂；;(trans-1,2-Cyclohexanediamine)oxalatoplatinum(II);[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum |
奥沙利铂信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于奥沙利铂报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途