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细胞裂解和提取物
吴茱萸碱
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 价格（元） | 操作 |
|---|---|---|---|
| E140884-1g | 518-17-2 | 询价 | |
| E140884-25g | 518-17-2 | 询价 | |
| E140884-5g | 518-17-2 | 询价 | |
| E101966-20mg | 518-17-2 | 195 | 询价 |
产品介绍
属性
| 熔点 | 278°C |
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | An antiangiogenic and antiinflammatory agonist of TRPV1. |
| 产品介绍 | Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects. |
| 生化机理 | The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine. |
| 别名 | 吴茱萸胺; |
吴茱萸碱信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于吴茱萸碱报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途