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细胞裂解和提取物
黄芩素
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 价格（元） | 操作 |
|---|---|---|---|
| B107324-100g | 491-67-8 | 询价 | |
| B107324-100mg | 491-67-8 | 询价 | |
| B107324-1g | 491-67-8 | 询价 | |
| B107324-25g | 491-67-8 | 询价 | |
| B107324-5g | 491-67-8 | 询价 | |
| B107323-20mg | 491-67-8 | 89 | 询价 |
产品介绍
- 分子式 C15H10O5
- 分子量270.24
- Beilstein号 272683
- EC号 MFCD00017459
- MDL号 MFCD00017459
- PubChem编号 24870246
属性
| 熔点 | 256-271°C |
| 敏感性 | 对光和热敏感 |
| 溶解性 | Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.5480 |
描述
| 应用 | An inhibitor of Ca2+ uptake, 5-LO, and 12-LO |
| 产品介绍 | Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9. |
| 生化机理 | 中药类黄酮的组成成分，黄芩的主要黄酮，抑制花生四烯酸代谢中的12-脂肪氧化酶路径（12-lipoxygenase ，12-LOX），此路径能抑制癌细胞的增殖，诱导凋亡途径。 |
| 别名 | 三羟黄酮;黄芩苷元;黄芩黄素;黄芩甙元;5,6,7-三羟基黄酮;5,6,7-Trihydroxyflavone |
黄芩素信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于黄芩素报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途