诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞裂解和提取物
紫杉醇
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 价格（元） | 操作 |
|---|---|---|---|
| P106869-1g | 33069-62-4 | 询价 | |
| P106869-250mg | 33069-62-4 | 询价 | |
| P106869-5g | 33069-62-4 | 询价 | |
| P106869-50mg | 33069-62-4 | 询价 | |
| P106869-10mg | 33069-62-4 | 询价 | |
| P106868-10mg | 33069-62-4 | 449 | 询价 |
产品介绍
- 分子式 C47H51NO14
- 分子量853.91
- Beilstein号 1420457
- EC号
- MDL号 MFCD00869953
- PubChem编号 24277878
属性
| 熔点 | 213-216°C |
| 旋光率 | -49 ° (C=1, MeOH) |
| 溶解性 | Soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度2-8°C |
| 密度 | 1.3900 |
描述
| 应用 | 有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。 |
| 产品介绍 | Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM |
| 生化机理 | Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf |
| 别名 | TaxolTaxol |
紫杉醇信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于紫杉醇报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途