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催化和无机化学
Jasplakinolide
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 价格（元） | 操作 |
|---|---|---|---|
| J132593-100μg | 102396-24-7 | 5999 | 询价 |
产品介绍
- 分子式 C36H45BrN4O6
- 分子量709.67
- Beilstein号
- EC号 MFCD00873735
- MDL号 MFCD00873735
- PubChem编号
属性
| 溶解性 | Soluble in DMSO (>2 mg/ml), water (partly), 100% ethanol, and 83% methanol |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A cell permeable compound which stabilizes pre-formed actin filaments and inhibits their disassembly. |
| 生化机理 | Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release. |
| 别名 | ;Jaspamide |
Jasplakinolide信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Jasplakinolide报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途