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催化和无机化学
6-(5H)-菲啶酮
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 价格（元） | 操作 |
|---|---|---|---|
| H137937-1g | 1015-89-0 | 299 | 询价 |
| H137937-25g | 1015-89-0 | 3999 | 询价 |
| H137937-5g | 1015-89-0 | 1199 | 询价 |
产品介绍
- 分子式 C13H9NO
- 分子量195.22
- Beilstein号
- EC号 213-804-3
- MDL号 MFCD00004988
- PubChem编号 24858050
属性
描述
| 应用 |
Reactant involved in: Synthesis of 5,6-dihydrophenanthridine sulfonamides. Oxidative coupling with diphenylacetylene. Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including: Potassium channel KV1.3 and IK-1 inhibitors. HIV-1 integrase inhibitors. |
| 产品介绍 | 6(5H)-Phenanthridinone is a small molecule poly(ADP-ribose) polymerase (PARP) inhibitor with immunosupperessive effects. 6(5H)-Phenanthridinone has been shown to inhibit concanavilin A-induced lymphocyte proliferation, producing the observed immunosuppressant activity of this compound. It has also been shown to potentiate the effect of ionizing radiation on developing cells, strongly increasing the radiation-induced inhibition of cell proliferation, which suggests use of 6(5H)-Phenanthridinone as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis versus treatment with DNA-damaging agents alone, indicating that PARP activity is involved in the apoptotic process. |
| 别名 | 6(5H)-5-氮杂菲酮;6(5H)-菲啶酮;6(5H)-Phenanthridinone;5,6-Dihydrophenanthridin-6-one;NSC 11021;NSC 40943;NSC 61083 |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途