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杂环砌块
Fasudil Hydrochloride
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 价格（元） | 操作 |
|---|---|---|---|
| F122336-100mg | 105628-07-7 | 499 | 询价 |
| F122336-1g | 105628-07-7 | 1399 | 询价 |
| F122336-250mg | 105628-07-7 | 719 | 询价 |
| F122336-500mg | 105628-07-7 | 999 | 询价 |
| F122336-5g | 105628-07-7 | 4999 | 询价 |
产品介绍
- 分子式 C14H17N3O2S·HCl
- 分子量327.83
- Beilstein号
- EC号
- MDL号 MFCD00943198
- PubChem编号
属性
| 沸点 | 506.2° C |
| 熔点 | 208-215° C |
| 折光率 | 1.62 |
| 溶解性 | Soluble in water (200 mg/mL), and DMSO (95 mg/mL). Insoluble in ethanol. |
描述
| 应用 | A selective ROCK inhibitor |
| 产品介绍 | Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1. |
| 生化机理 | 盐酸法舒地尔能抑制ROCK-II，PKA，PKG，PKC和MLCK，Ki分别为0.33 μM，1.6 μM，1.6 μM，3.3 μM和36 μM。 |
| 别名 | 盐酸法舒地尔; (5-异喹啉磺酰基)高哌嗪盐酸盐;5-(1-高哌嗪)磺酰基异喹啉盐酸盐;5-(1-Homopiperazinyl)sulfonylisoquinoline Hydrochloride; 1-(5-Isoquinolinesulfonyl)homopiperazine Hydrochloride; HY-10341; HA-1077; AT-877; Fasudil; Fasudil HCl |
Fasudil Hydrochloride信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Fasudil Hydrochloride报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途