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催化和无机化学
顺铂
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 价格（元） | 操作 |
|---|---|---|---|
| D109812-1g | 15663-27-1 | 999 | 询价 |
| D109812-250mg | 15663-27-1 | 449 | 询价 |
| D109812-5g | 15663-27-1 | 3949 | 询价 |
产品介绍
- 分子式 H6Cl2N2Pt
- 分子量300.1
- Beilstein号
- EC号
- MDL号 MFCD00011623
- PubChem编号
属性
| 熔点 | 270°C |
| 敏感性 | 对湿度敏感&对光敏感 |
| 溶解性 | Soluble in DMSO (25 mg/ml), water (0.25 g/100ml) at 25 °C, ethanol (<1 mg/ml) at 25 °C, and DMF (16 mg/ml) |
| 存贮条件 | 充氩保存 |
| 密度 | 3.7000 |
描述
| 应用 |
cis-Diamineplatinum(II) dichloride can be used as a model drug to test the efficiency of various drug carriers in drug delivery. cis-Diammineplatinum(II) dichloride has been used: · in cell viability measurement in cochlear explants · in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines · in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma |
| 产品介绍 | 微溶于水，易溶于二甲基甲酰胺。在水溶液中可逐渐转化成反式和水解。 |
| 生化机理 | Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks. Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. |
| 别名 | 顺双氯双氨络铂，氯氨铂，顺二氯二氨基铂;顺式-二胺二氯铂;顺-二胺二氯铂(II);顺氯氨铂;cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; cis-Diammineplatinum(II) dichloride ; Cisplatin |
顺铂信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于顺铂报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途