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D-赤型鞘氨醇-1-磷酸,26993-30-6,≥98.0%
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 总代理 | 中国 | 现货 |
性能特点
D-erythro-Sphingosine-1-phosphate(S1P) is a polar sphingolipid metabolite which regulates divers
货号 | 规格 | CAS号 | 价格 | 操作 |
---|---|---|---|---|
D130606-1mg | 1mg | 26993-30-6 | ¥2,018.90 | 询底价 |
D130606-5mg | 5mg | 26993-30-6 | ¥6,076.90 | 询底价 |
中文名:D-赤型鞘氨醇-1-磷酸
英文名:D-erythro-sphingosine-1-phosphate
英文别名:sphingosine-1-phosphate|Sphingosine 1-phosphate|26993-30-6|D-erythro-Sphingosine-1-phosphate|C18-Sphingosine 1-phosphate|D-erythro-sphingosine 1-phosphate|S1P|Sphing-4-enine 1-phosphate|CHEBI:37550|Sphingosine 1-phosphic acid|(2S,3R,4E)-2-amino-3-hydroxyo
纯度:≥98.0%
货号:D130606
Cas号:26993-30-6
存储温度:-20°C储存,充氩
产品介绍:
D-erythro-Sphingosine-1-phosphate(S1P) is a polar sphingolipid metabolite which regulates diverse cellular responses including cell growth, survival and migration. S1P was reported to stimulate DNA synthesis and cell division in quiescent cultures of Swiss 3T3 fibroblasts and to trigger the dual signal transduction pathways of calcium mobilization and PC-PLD (phospholipase D) activation. S1P serves as a second messenger for intracellular calcium mobilization in U-937 cells and decreases cellular cAMP. Recent studies show that S1P is a G-protein-coupled receptor (GPCR) ligand for the EDG-1 family, including EDG-1, -3, -5, -6 and -8. This bioactive lipid mediator has been shown to stimulate the ERK pathway and to also counteract the ceramide-induced activation of stress-activated protein kinase (SAPK/JNK). Researchers have also found that S1P is a strong inhibitor of cell motility and phagokinesis in B16 melanoma cells. Additionally, it induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells. S1P has also been known as a tumor-promoting lipid. Sμggested to be an activator of GPR3, GPR6, and GPR12. D-erythro-Sphingosine-1-phosphate is an activator of EDG-1, EDG-3, EDG-2, EDG-4 and EDG-5.A ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途