盐酸法舒地尔，105628-07-7，98%

中文名：盐酸法舒地尔

英文名：Fasudil Hydrochloride

中文别名：盐酸法舒地尔|5-(1-高哌嗪)磺酰基异喹啉盐酸盐|(5-异喹啉磺酰基)高哌嗪盐酸盐

英文别名：Fasudil hydrochloride|105628-07-7|Fasudil HCl|Eril|Fasudil (HA-1077) HCl|5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride|Fasudil (Hydrochloride)|AT-877|Fasudil Monohydrochloride|ha-1077|SQ04N8S7BR|Fasudil, Monohydrochloride Salt|DTXSID1045615|MF

纯度：98%

货号：F122336

Cas号：105628-07-7

存储温度：避光,-20°C储存

产品介绍：

Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies sμggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.A selective ROCK inhibitor

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