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格尔德霉素,30562-34-6,≥98% (HPLC)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 总代理 | 中国 | 现货 |
性能特点
λmax 305(MeOH)(Lit.) A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc
货号 | 规格 | CAS号 | 价格 | 操作 |
---|---|---|---|---|
G102383-10mg | 10mg | 30562-34-6 | ¥985.90 | 询底价 |
G102383-250mg | 250mg | 30562-34-6 | ¥6,117.90 | 询底价 |
G102383-50mg | 50mg | 30562-34-6 | ¥3,015.90 | 询底价 |
中文名:格尔德霉素
英文名:Geldanamycin from Streptomyces hygroscopicus
英文别名:geldanamycin|30562-34-6|CHEBI:5292|NSC-122750|Z3K3VJ16KU|U-29135|[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate|GDM|(4E,6Z,8S,9S,10E
纯度:≥98% (HPLC)
货号:G102383
Cas号:30562-34-6
存储温度:-20°C储存
产品介绍:
λmax 305(MeOH)(Lit.) A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Geldanamycin has antiproliferative and antitumor effects. Rapidly depletes p185c-erbB2 protein tyrosine kinase in breast carcinoma cells. Binds to HSP90 and disrupts Raf1-HSP90 complex leading to destabilization of Raf1. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase activity. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines. A benzoquinoid antibiotic that is a potent inhibitor of pp60src tyrosine kinase. Geldanamycin has antiproliferative and antitumor effects. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal Kinase activity. Binds to HSP90 and disrupts raf1-HSP90 complex leading to destabilizing of Raf1. Also destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits c-myc expression in murine lymphoblastoma cells. Approximately ten-fold more potent than herbimycin A
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途