孕二烯酮，60282-87-3，98%

中文名：孕二烯酮

英文名：Gestodene

中文别名：孕二烯酮|SHB 331|WL 70|17alpha-乙炔-13-乙基-17beta-羟基-4,1

英文别名：GESTODENE|60282-87-3|Gestoden|Gestodenum [INN-Latin]|Gestodeno [INN-Spanish]|SH B 331|SH-B-331|DTXSID6046478|1664P6E6MI|13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregna-4,15-dien-20-yn-3-one|(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9

纯度：98%

货号：G304109

Cas号：60282-87-3

存储温度：-20°C储存

产品介绍：

Gestodene(SHB 331;WL 70) is a progestogen hormonal contraceptive. Target: Estrogen Receptor/ERR Gestodene is androgenically neutral, meaning that contraceptive pills containing gestodene do not exhibit the androgenic side effects (e.g. acne, hirsutism, weight gain) often associated with second-generation contraceptive pills, such as those containing levonorgestrel. When 40 micrograms of gestodene was taken, six out of seven women did not ovulate, and one out of seven had a cycle with luteal insufficiency. These data indicate that 40 micrograms of gestodene is the borderline dose for inhibition of ovulation. A combination of 75 micrograms gestodene with 30 micrograms ethinyl estradiol was found to inhibit ovulation in ten subjects, and no follicular maturation was noted . gestodene bound with high affinity to the progesterone receptor, as did other synthetic and natural progestogens. However, gestodene did not bind to the estradiol receptor. The relative binding affinities of all tested synthetic and natural ligands showed no organ-specific differences and no differences between neoplastically transformed and normal tissues . Clinical indications: Female contraception

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