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Ipragliflozin,761423-87-4,10mM in DMSO
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 总代理 | 中国 | 现货 |
性能特点
Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 2.8 nM; li
货号 | 规格 | CAS号 | 价格 | 操作 |
---|---|---|---|---|
I425869-1ml | 1ml | 761423-87-4 | ¥859.90 | 询底价 |
中文名:Ipragliflozin
英文名:Ipragliflozin
中文别名:(1S)-1,5-脱水-1-C-[3-[(1-苯并噻吩-2-基)甲基]-4-氟苯基]-D-葡糖醇
英文别名:Ipragliflozin|761423-87-4|suglat|ASP1941|ASP-1941|Ipragliflozin [INN]|Ipragliflozin (ASP1941)|(2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol|3N2N8OOR7X|CHEMBL2018096|(1S)-1,5-Anhydro-1-c-[3-[(1-benzot
纯度:10mM in DMSO
货号:I425869
Cas号:761423-87-4
存储温度:-80℃储存
产品介绍:
Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6. IC50 value: 2.8 nM Target: SGLT2 in vitro: Ipragliflozin potently and selectively inhibited human, rat, and mouse SGLT2 at nanomolar ranges and exhibited stability against intestinal glucosidases. in vivo: Ipragliflozin showed good pharmacokinetic properties following oral dosing, and dose-dependently increased urinary glucose excretion, which lasted for over 12 h in normal mice. Oral administration of ipragliflozin increased urinary glucose excretion in a dose-dependent manner, an effect which was significant at doses of 0.3 mg/kg or higher and lasted over 12 h. Single administration of ipragliflozin dose-dependently increased urinary glucose excretion, reduced blood glucose and plasma insulin levels, and improved glucose intolerance .
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途