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Netupitant，290297-26-6，2mM in DMSO
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 总代理 | 中国 | 现货 |
性能特点
InformationNetupitant Netupitant (CID6451149) is a selective neurokinin 1 (NK1) receptor antagon
| 货号 | 规格 | CAS号 | 价格 | 操作 |
|---|---|---|---|---|
| N423021-1ml | 1ml | 290297-26-6 | ￥514.90 | 询底价 |
中文名：Netupitant
英文名：Netupitant
英文别名：Netupitant|290297-26-6|2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide|2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanami
纯度：2mM in DMSO
货号：N423021
Cas号：290297-26-6
存储温度：-80℃储存
产品介绍：
Information
Netupitant Netupitant (CID6451149) is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.
Targets
Neurokinin-1 receptor
In vitro
In CHO NK1 cells, Netupitant concentration-dependently antagonizes the stimulatory effects of substance P (SP) showing insurmountable antagonism (pKB 8.87). In cells expressing NK2 or NK3 receptors, Netupitant is inactive.
In vivo
Netupitant behaves as a brain penetrant, orally active, potent and selective NK1 antagonist. In mice the intrathecal injection of SP elicited the typical scratching, biting and licking response that is dose-dependently inhibited by Netupitant given intraperitoneally in the 1-10 mg/kg dose range. In gerbils, foot tapping behavior evoked by the intracerebroventricular injection of a NK1 agonist is dose-dependently counteracted by Netupitant given intraperitoneally (ID50 1.5 mg/kg) or orally (ID50 0.5 mg/kg). In time course experiments in gerbils Netupitant displayed long lasting effects.
Cell Research(from reference)
Cell lines：NG108-15 cells
Concentrations：1, 3, 10, 30 nM
Incubation Time：1 h
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