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奥马维洛酮(RTA-408)，1474034-05-3，10mM in DMSO
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 总代理 | 中国 | 现货 |
性能特点
InformationOmaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that acti
| 货号 | 规格 | CAS号 | 价格 | 操作 |
|---|---|---|---|---|
| O421719-1ml | 1ml | 1474034-05-3 | ￥759.90 | 询底价 |
中文名：奥马维洛酮(RTA-408)
英文名：Omaveloxolone (RTA-408)
英文别名：Omaveloxolone|1474034-05-3|RTA-408|RTA 408|Nrf1-activator-1|SKYCLARYS|Omaveloxolone [INN]|UNII-G69Z98951Q|G69Z98951Q|Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-|N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9
纯度：10mM in DMSO
货号：O421719
Cas号：1474034-05-3
存储温度：-80℃储存
产品介绍：
Information
Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
Targets
NF-κB ; Nrf2
In vitro
RTA 408 potently increases expression of Nrf2 target genes and reverses IFNγ-mediated suppression of Gclc expression in RAW 264.7 cells. In a panel of eight human tumor cell lines, RTA 408 inhibits growth with an average GI50 value of 260 nM and induces apoptosis. RTA 408 also inhibits NF-κB and activates JNK in tumor cells.
In vivo
In mice with radiation-induced dermatitis, 1.0% RTA 408 markedly reduces epidermal and collagen thickening, prevents dermal necrosis and completely alleviates skin ulcers. In rat skin, RTA 408 activates Nrf2 and induces cytoprotective genes. RTA 408 also mitigates hematopoietic acute radiation syndrome in mice.
Cell Research(from reference)
Cell lines：A375, NCI-H460, A2058, MDA-Mb-231, HCT116, 786-0, A549, and PANC-1 cells
Concentrations：~1 μM
Incubation Time：72 hours
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途
