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瑞卢戈利,737789-87-6,10mM in DMSO
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 总代理 | 中国 | 现货 |
性能特点
InformationRelugolix Relugolix (RVT-601, TAK-385) is a selective antagonist of the gonadotropin-
货号 | 规格 | CAS号 | 价格 | 操作 |
---|---|---|---|---|
R425755-1ml | 1ml | 737789-87-6 | ¥205.90 | 询底价 |
中文名:瑞卢戈利
英文名:Relugolix
英文别名:Relugolix|737789-87-6|TAK-385|Orgovyx|TAK 385|1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea|UNII-P76B05O5V6|P76B05O5V6|Relugolix(TAK-385)|CH
纯度:10mM in DMSO
货号:R425755
Cas号:737789-87-6
存储温度:-80℃储存
产品介绍:
Information
Relugolix Relugolix (RVT-601, TAK-385) is a selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with IC50 of 0.33 nM and 0.32 nM for human GnRHR and monkey GnRHR, respectively.
Targets
monkey GnRHR (Cell-free assay); human GnRHR (Cell-free assay) 0.32 nM; 0.33 nM
In vitro
Relugolix (TAK-385) possesses higher affinity and potent antagonistic activity for human (binding IC50=0.33 nM in the presence of serum) and monkey GnRH receptor (IC50=0.32 nM), but has low affinity for the rat GnRH receptor (IC50=9800 nM).
In vivo
TAK-385 acts as an antagonist for human GnRH receptor in vivo and daily oral administration potently, continuously and reversibly suppresses the hypothalamic-pituitary-gonadal axis.
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途