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桔皮素,481-53-8,10mM in DMSO
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 总代理 | 中国 | 现货 |
性能特点
InformationTangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel
货号 | 规格 | CAS号 | 价格 | 操作 |
---|---|---|---|---|
T408390-1ml | 1ml | 481-53-8 | ¥801.90 | 询底价 |
中文名:桔皮素
英文名:Tangeretin
英文别名:Tangeritin;4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-
纯度:10mM in DMSO
货号:T408390
Cas号:481-53-8
存储温度:-80℃储存
产品介绍:
Information
Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.
In vitro
Tangeretin is a polymethoxylated flavonoid concentrated in the peel of citrus fruits. Recent studies have shown that tangeretin exhibits anti-proliferative, anti-invasive, anti-metastatic, and antioxidant activities. Tangeretin at 2.7 μM induces apoptosis in human promyelocytic leukaemia HL-60 cells, whereas the flavone showed no cytotoxicity against human peripheral blood mononuclear cells (PBMCs). Further study shows that tangeretin at 50 μM exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins such as Cdk2 and Cdk4, and mediates the increase of Cdk inhibitors p21 and p27. Pretreatment with tangeretin inhibites IL-1beta-induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB in human lung epithelial carcinoma cells (A549) and and human non-small cell lung carcinoma cells (H1299).
In vivo
Cell Data
cell lines:
Concentrations:
Incubation Time:
Powder Purity:≥97%
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途