HY-14645A (+)-DHMEQ | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 6000 |
性能特点
(+)-DHMEQ 是一种抗氧化转录因子 Nrf2 的激活剂。(+)-DHMEQ 是 (-)-DHMEQ 的对映体。(+)-DHMEQ 抑制 NF-kB 的活性低于(-)-DHMEQ。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 287194-41-6 | ¥2,011.00 | 询底价 |
2 mg | 287194-41-6 | ¥1,400.00 | 询底价 |
5 mg | 287194-41-6 | ¥2,200.00 | 询底价 |
10 mg | 287194-41-6 | ¥3,000.00 | 询底价 |
25 mg | 287194-41-6 | ¥6,000.00 | 询底价 |
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CAS No. : 287194-41-6
MCE 国际站:(+)-DHMEQ
产品活性:(+)-DHMEQ 是一种抗氧化转录因子 Nrf2 的激活剂。(+)-DHMEQ 是 (-)-DHMEQ 的对映体。(+)-DHMEQ 抑制 NF-kB 的活性低于(-)-DHMEQ。
研究领域:NF-κB
作用靶点:Keap1-Nrf2
In Vitro: (+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.
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