HY-132202 PD-1/PD-L1-IN-10 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 11500 |
性能特点
PD-1/PD-L1-IN-10 (compound B2) 是具有口服活性的 PD-1/PD-L1 抑制剂 (IC50 of 2.7 nM),具有抗肿瘤活性。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 2487550-41-2 | ¥1,430.00 | 询底价 |
5 mg | 2487550-41-2 | ¥1,300.00 | 询底价 |
10 mg | 2487550-41-2 | ¥2,100.00 | 询底价 |
50 mg | 2487550-41-2 | ¥7,200.00 | 询底价 |
100 mg | 2487550-41-2 | ¥11,500.00 | 询底价 |
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PD-1/PD-L1-IN-10
CAS No. : 2487550-41-2
MCE 国际站:PD-1/PD-L1-IN-10
产品活性:PD-1/PD-L1-IN-10 (compound B2) 是具有口服活性的 PD-1/PD-L1 抑制剂 (IC50 of 2.7 nM),具有抗肿瘤活性。
研究领域:Immunology/Inflammation | Apoptosis
作用靶点:PD-1/PD-L1 | Apoptosis
In Vitro: PD-1/PD-L1-IN-10 (compound B2) significantly promotes interferongamma secretion in a dose-dependent manner in vitro even at the low concentration of 1 nM.
PD-1/PD-L1-IN-10 (compound B2) does not affect cell viability of LLC cells and lymph node T-cells.
PD-1/PD-L1-IN-10 (compound B2, 0-100 nM) stabilizes the PD-L1 protein in mouse Lewis lung carcinoma (LLC) cells. In particular, PD-1/PD-L1-IN-10 (compound B2) maintains the PD-L1 stability in a dose-dependent manner at 58 °C. Suggesting that PD-1/PD-L1-IN-10 (compound B2) could enter LLC cells and then directly binds to the PD-L1 protein.
In Vivo: PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy in an LLC-bearing allograft mouse model. PD-1/PD-L1-IN-10 (compound B2) effectively blocks tumor cell proliferation and induces apoptosis in LLC tumor tissues..
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