HY-D1056 Lipopolysaccharides | MedChemExpress (MCE)

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Lipopolysaccharides

CAS No. :

MCE 国际站：Lipopolysaccharides

产品活性：Lipopolysaccharides (LPS) 脂多糖是从革兰氏阴性菌外膜的外叶中提取的内毒素，由一个抗原 O- 特异性链、一个核心寡糖和脂质 A 构成。Lipopolysaccharides 是一种激活免疫系统的致病相关分子模式 (PAMP)。Lipopolysaccharides 激活免疫细胞的 TLR-4。 本产品来源于大肠杆菌 O55:B5。Lipopolysaccharides 诱导细胞迁移体的分泌。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

结构分类：糖类  |  结构分类

In Vitro: Lipopolysaccharides (10–80 μg/mL) selectively decreases THir (tyrosine hydroxylase immunoreactive) cells and increases culture media levels of interleukin1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as nitrite (an index of nitric oxide (NO) production).

In Vivo: Lipopolysaccharides can be used in animal modeling to construct a mouse liver inflammation model.

Lipopolysaccharides (1.5 mg/kg; i.p.; once) induces sickness and hypothermia in mice, and induces a greater and more prolonged sickness response in adult male mice.

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