HY-P72677 GCP-2/CXCL6 Protein, Human (HEK293, His) | MedChemExpress (MCE)

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GCP-2/CXCL6 Protein, Human (HEK293, His)

MCE 国际站：GCP-2/CXCL6 Protein, Human (HEK293, His)

CXCL6 (也称为粒细胞趋化蛋白-2，GCP-2) 是 ELR+ CXC 趋化因子家族的成员，是中性粒细胞的趋化因子，通过趋化因子受体 CXCR1 和 CXCR2 启动趋化性。CXCL6 发挥中性粒细胞活化和血管生成活性，并对革兰氏阴性菌和革兰氏阳性菌具有抗菌作用。GCP-2/CXCL6 Protein, Human (HEK293, His) 在 HEK293 细胞中表达产生，由 77 个氨基酸 (G38-N114) 组成，并在 C 末端带有 6 个 His 标签。

Synonyms: C-X-C motif chemokine 6; CKA-3; GCP-2; CXCL6; GCP2; SCYB6

Species: Human

Source: HEK293

研究背景：CXCL6 (also known as GCP-2) is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. Through binding and activation of its receptors (CXCR1 and CXCR2), it exerts neutrophil-activating and angiogenic activities. In addition, CXCL6 also has antibacterial effects.
CXCL6 is an ELR-positive CXC chemokine with a length of 77 amino acids. The NH2-terminal glutamic acid-leucine-arginine (ELR) motif is characteristic of CXC chemokines interacting with the G-protein-coupled receptors CXCR1 and CXCR2. The ELR+ CXC family which includes IL-8, the growth-regulated oncogenes (GRO-α,-β-γ), and ENA-78. The structure of CXCL6 is >75% homologous to ENA-78, but is unique in that it binds with high-affinity to both CXCR1 and CXCR2. GCP-2, similar to IL-8, activates target cells by binding to CXCR-1 and CXCR-2. Both receptors are expressed by neutrophil granulocytes, but not by other blood-derived cells, such as lymphocytes or monocytes. Activation of endothelial cells by CXCL6 causes a mitogenic response, resulting in angiogenesis. CXCL2 is expressed by epithelial cells of the airways, eyes, gastrointestinal tract, mammary glands, tonsils, macrophages, and mesenchymal cells, in particular during inflammation. Lipopolysaccharides (LPS) and the proinflammatory cytokines TNF-α and IL-1β up-regulate the expression of CXCL6, while gamma interferon has a down-regulating effect.
CXCL6 mediates several processes such as inflammation, immunoreaction, cell growth, and metastasis through interaction with the chemokine receptors CXCR1 and CXCR2 in humans. CXCL6 possesses potent chemotactic and proangiogenic properties. CXCL6 is over expressed in colorectal, breast, lung and thyroid cancers. In addition, CXCL6 shows antibacterial activity against gram-positive and gram-negative pathogenic bacteria of relevance to mucosal infections is seen at submicromolar concentrations.

蛋白编号：P80162 (G38-N114)

基因 ID：6372

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 6

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  CXCL6

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