L-NAME hydrochloride | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 900 |
性能特点
L-NAME hydrochloride是 NOS 的抑制剂,IC50 为70 μM。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 51298-62-5 | ¥550.00 | 询底价 |
100 mg | 51298-62-5 | ¥500.00 | 询底价 |
500 mg | 51298-62-5 | ¥900.00 | 询底价 |
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CAS No. : 51298-62-5
MCE 国际站:L-NAME hydrochloride
产品活性:L-NAME hydrochloride是 NOS 的抑制剂,IC50 为70 μM。
作用靶点:NO Synthase
In Vitro: L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with Nw-nitro-L-arginine methyl ester (L-NAME) being at the head. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC50= 70 μM) than L-NOARG (IC50= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG.
In Vivo: L-NAME hydrochloride can be used in animal modeling to construct cardiovascular and cerebrovascular disease models.
L-NAME infusion significantly decreases NKT-leukocyte level, tumor-necrosis factor (TNF)-alpha production by T-splenocytes and macrophages, and IFNγ production by T-leukocytes, monocytes, and T-splenocytes, as well as increased interleukin-6 production by T-leukocytes and monocytes and nitrate/nitrite production by T-leukocytes. There is increasing evidence that nitric oxide may be involved in learning and memory. l-NAME produces a task-dependent impairment of fear extinction, and implies that nitric oxide signaling is involved in memory process of certain fear extinction tasks. Chronic L-NAME administration induces cardiac hypertrophy in rodent models. Six weeks L-NAME administration induces significant cardiac hypertrophy compared to control hearts.
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途