SN 2 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 4680 |
性能特点
SN 2 是一种有效的 TRPML3 离子通道激活剂,EC50 为 1.8 μM。SN 2 还是登革热病毒 2 (DENV2) 和寨卡病毒 (ZIKV) 的有效抑制剂。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 823218-99-1 | ¥808.00 | 询底价 |
5 mg | 823218-99-1 | ¥735.00 | 询底价 |
10 mg | 823218-99-1 | ¥1,120.00 | 询底价 |
50 mg | 823218-99-1 | ¥4,680.00 | 询底价 |
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CAS No. : 823218-99-1
MCE 国际站:SN 2
产品活性:SN 2 是一种有效的 TRPML3 离子通道激活剂,EC50 为 1.8 μM。SN 2 还是登革热病毒 2 (DENV2) 和寨卡病毒 (ZIKV) 的有效抑制剂。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:TRP Channel
In Vitro: The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel.
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