Cinanserin hydrochloride | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 9750 |
性能特点
Cinanserin hydrochloride (SQ 10643) 是一种有效,选择性和高度亲和力的 5-HT2 受体拮抗剂,Ki 为 41 nM。Cinanserin hydrochlo
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 54-84-2 | ¥2,805.00 | 询底价 |
10 mg | 54-84-2 | ¥2,550.00 | 询底价 |
50 mg | 54-84-2 | ¥6,500.00 | 询底价 |
100 mg | 54-84-2 | ¥9,750.00 | 询底价 |
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CAS No. : 54-84-2
MCE 国际站:Cinanserin hydrochloride
产品活性:Cinanserin hydrochloride (SQ 10643) 是一种有效,选择性和高度亲和力的 5-HT2 受体拮抗剂,Ki 为 41 nM。Cinanserin hydrochloride 对 5-HT2 的结合亲和力比对 5-HT1 受体 (Ki 为 3500 nM) 的结合亲和力高得多。Cinanserin hydrochloride 还是COVID-19 病毒的 3C 样蛋白酶 (3C-like proteinase) 的抑制剂,可大大减少体外的病毒复制。
研究领域:GPCR/G Protein | Neuronal Signaling | Anti-infection
作用靶点:5-HT Receptor | Influenza Virus
In Vitro: Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CLpro.
The IC50 values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CLpro are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC50 values for HCoV-229E 3CLpro are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3Cpro at concentrations up to 200 μM.
In Vivo: Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
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