LDN-192960 hydrochloride | MedChemExpress (MCE)

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

LDN-192960 hydrochloride

CAS No. : 2309172-48-1

MCE 国际站：LDN-192960 hydrochloride

产品活性：LDN-192960 hydrochloride 是 Haspin 和 DYRK2 的双重抑制剂，IC₅₀ 值分别为 10 nM 和 48 nM。

研究领域：Cell Cycle/DNA Damage  |  Protein Tyrosine Kinase/RTK

作用靶点：Haspin Kinase  |  DYRK

In Vitro: LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC₅₀<1 μM), including CLK1 (IC₅₀=0.21 μM), DYRK1A (IC₅₀= 0.10 μM), DYRK2 (IC₅₀=2 nM), DYRK3 (IC₅₀=19 nM) and PIM1 (IC₅₀=0.72 μM).
LDN-0192960 hydrochloride (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC₅₀ of 1.17 μM.
LDN-0192960 hydrochloride (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC₅₀ of 0.02 μM.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Anti-Obesity Compound Library  |  Targeted Diversity Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  ID-8  |  Dyrk1A/α-synuclein-IN-1  |  LDN-192960  |  DYRK1-IN-1  |  DYRKs-IN-2  |  Dyrk1A-IN-5  |  INDY  |  CK2/ERK8-IN-1  |  MBM-55S  |  T025  |  Protein kinase inhibitor 1  |  Haspin-IN-3  |  JH-XIV-68-3  |  ML167  |  Dyrk1A-IN-4  |  GNF2133 hydrochloride  |  ILK-IN-3  |  AZ191  |  CLK-IN-T3  |  Aristolactam A IIIa  |  Harmine hydrochloride  |  AZ-Dyrk1B-33  |  tBID  |  HTH-01-091  |  Mirk-IN-1  |  EHT 5372  |  EHT 1610  |  CLK1-IN-3  |  GNF4877  |  Dyrk1A-IN-2

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-13455A

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。