PJ34 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 3000 |
性能特点
PJ34 是一种有效的特异性 PARPl/2 抑制剂,IC50 分别为 110 nM 和 86 nM。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 344458-19-1 | ¥660.00 | 询底价 |
10 mg | 344458-19-1 | ¥570.00 | 询底价 |
50 mg | 344458-19-1 | ¥1,700.00 | 询底价 |
100 mg | 344458-19-1 | ¥3,000.00 | 询底价 |
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CAS No. : 344458-19-1
MCE 国际站:PJ34
产品活性:PJ34 是一种有效的特异性 PARPl/2 抑制剂,IC50 分别为 110 nM 和 86 nM。
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:PARP
In Vitro: PJ34 inhibits the PARP enzyme activity with an IC50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10-7 to 10-5 M.
In Vivo: To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途