IL-15 蛋白, Human | MedChemExpress (MCE)

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IL-15 Protein, Human

MCE 国际站：IL-15 Protein, Human

IL-15 Protein, Human是一种多效细胞因子，包括 T，B 和 NK 细胞刺激活性。

Synonyms: rHuIL-15; IL15

Species: Human

Source: E. coli

Biological Activity: 1. The ED₅₀ is <0.5 ng/mL as measured by CTLL-2 cells, corresponding to a specific activity of >2 × 10⁶ units/mg.
2.The ED₅₀ is less than 2 ng/mL, as measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.

研究背景：Interleukin 15 is a cytokine that shares many biological properties with IL-2, including T, B and NK cell-stimulatory activities. Interleukin-15 has significant potential in cancer immunotherapy as an activator of antitumor CD8 T and natural killer (NK) cells. Interleukin-15 (IL-15) is a pleiotropic cytokine and a member of the four α-helix bundle family of cytokines which include IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. IL-15 exhibits a broad biological activity and induces the differentiation and proliferation of T, B and natural killer (NK) cells. As a potent pro-inflammatory cytokine, IL-15 plays an important and complex role in autoimmune disease and inflammation. IL-15 plays a pivotal role in some hematological malignancies and presents anti-tumor effects. The direct administration of IL-15 has shown anti-tumor effects in several preclinical mouse tumor models.

蛋白编号：P40933 (N49-S162)

基因 ID：3600

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-15

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-15

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