Glycocholic acid sodium | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 385 |
性能特点
Glycocholic acid sodium 是具有口服活性的抗肿瘤活性的胆汁酸,可靶向作用于耐药泵和非耐药泵通路。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 863-57-0 | ¥385.00 | 询底价 |
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Glycocholic acid sodium
CAS No. : 863-57-0
MCE 国际站:Glycocholic acid sodium
产品活性:Glycocholic acid sodium 是具有口服活性的抗肿瘤活性的胆汁酸,可靶向作用于耐药泵和非耐药泵通路。
研究领域:Metabolic Enzyme/Protease
作用靶点:Endogenous Metabolite
In Vitro: Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways.
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