Lonidamine | 氯尼达明 | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 567 |
性能特点
Lonidamine (AF-1890) 是一种己糖激酶 (hexokinase) 和丙酮酸载体 (mitochondrial pyruvate carrier) 抑制剂 (Ki: 2.5 μ
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mM * 1 mL | 50264-69-2 | ¥567.00 | 询底价 |
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Lonidamine
CAS No. : 50264-69-2
MCE 国际站:Lonidamine
产品活性:Lonidamine (AF-1890) 是一种己糖激酶 (hexokinase) 和丙酮酸载体 (mitochondrial pyruvate carrier) 抑制剂 (Ki: 2.5 μM)。Lonidamine 还可抑制癌细胞中的有氧糖酵解。Lonidamine 可用于线粒体代谢和炎症的研究,如肺纤维化。
研究领域:Metabolic Enzyme/Protease | Apoptosis | Anti-infection
作用靶点:Hexokinase | Mitochondrial Metabolism | Apoptosis | Parasite
In Vitro: Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.
Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.
Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.
Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.
Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.
In Vivo: Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.
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