PCI 29732 | MedChemExpress (MCE)

PCI 29732 产品活性：PCI 29732 是一种有效的可逆 BTK 抑制剂，对 BTK、Lck 和 Lyn 的 Kiapp 值分别为 8.2、4.6 和 2.5 nM。PCI 29732 对另一种 Tec 家族激酶 Itk 仅有适度的抑制活性。PCI 29732 通过竞争性结合ABCG2 的 ATP 结合位点来抑制 ABCG2 的功能。 产品来源： https://www.medchemexpress.cn/PCI-29732.html 研究领域：Protein Tyrosine Kinase/RTK | Membrane Transporter/Ion Channel 作用靶点：Btk | BCRP In Vitro: PCI29732 shows cytotoxicity in different cells. The IC50 values are 7.94 μM for S1, 7.79 μM for S1-MI-80, 6.55 μM for H460, 6.34 μM for H460/MX20, 6.14 μM for KB, 6.02 μM for KBv200, 12.45 μM for HEK293/pcDNA3, 14.58 μM for HEK293-ABCG2-482-R2, and 13.24 μM for HEK293-ABCG2-482-T7 cells. PCI-29732 blocks the transcriptional up-regulation of a panel of B-cell activation genes in human CD20+ B cells stimulated at the B-cell antigen receptor (BCR). In Vivo: PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 and enhances the anti-tumor efficacy of substrate chemotherapeutic agents. PCI 29732 (20 mg/kg; p.o.; every 3 d × 5 times) enhances the anticancer efficacy of Topotecan in the H460/MX20 cell xenograft nude mice model. 相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Membrane Transporter/Ion Channel Compound Library | Protein Tyrosine Kinase Compound Library | Covalent Screening Library | Orally Active Compound Library | Anti-Blood Cancer Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Autoimmune Disease Compound Library | Anti-Drug-Resistant Compound Library | Anti-Hematopathy Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Ibrutinib | Acalabrutinib | Ko 143 | Elacridar | Pirtobrutinib | Zanubrutinib | Fenebrutinib | CP-100356 hydrochloride | Remibrutinib | Tolebrutinib | Fumitremorgin C | Nemtabrutinib | Sunvozertinib | Orelabrutinib | Tirabrutinib | NX-2127 | Rilzabrutinib | Spebrutinib | Ibrutinib-biotin | Branebrutinib | QL47 | BMX-IN-1 | MT-802 | Luxeptinib | NX-5948 | Vecabrutinib | (Z)-LFM-A13 | CGI-1746 | Moxidectin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

PCI 29732 | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供，如您想了解更多关于PCI 29732 | MedChemExpress (MCE)报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途