Eprosartan mesylate | 甲磺酸依普罗沙坦 | MedChemExpress (MCE)

Eprosartan mesylate 产品活性：Eprosartan mesylate (SKF-108566J) 是一种选择性，竞争性，非肽和具有口服活性的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，可用作降压剂。Eprosartan mesylate 结合血管紧张素 II 受体，在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。 产品来源： https://www.medchemexpress.cn/Eprosartan-mesylate.html 研究领域：GPCR/G Protein 作用靶点：Angiotensin Receptor In Vitro: Eprosartan (SKF-108566J) inhibits [125I]AII binding to human liver membranes (IC50 of 1.7 nM) and to rat mesenteric artery membranes (IC50 of 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca2+ levels. In Vivo: In conscious normotensive rats, i.v. administration of Eprosartan (0.01-0.3 mg/kg) produced dose-dependent parallel shifts in the AII pressor dose-response curve. Administration of Eprosartan (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.). At 10 mg/kg, i.d., significant inhibition of the pressor response to AII was observed for 3 hr. 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Anti-COVID-19 Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Angiogenesis-Related Compound Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Heterocyclic Compound Library | Off-patent Drug Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Bioactive Compound Library Max | Angiotensin II human | Losartan | Telmisartan | Tranilast | Valsartan | A 779 | Buloxibutid | AVE 0991 | Irbesartan | Candesartan | Nitrosoglutathione | YS-49 | Olmesartan | Olodanrigan | PD 123319 ditrifluoroacetate | Sparsentan | Alamandine | Azilsartan medoxomil | CGP-42112 | Talfirastide acetate | TRV-120027 | Angiotensin III, human, mouse | Angiotensin II 5-valine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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