BRD4770 | MedChemExpress (MCE)

BRD4770 产品活性：BRD4770 是一种组蛋白甲基转移酶 G9a 抑制剂。BRD4770 可抑制 H3K9 的二甲基和三甲基化，EC50 为 5 µM，对 H3K27me3，H3K36me3，H3K4me3 和 H3K79me3 几乎没有影响。BRD4770 可以激活共济失调毛细血管扩张突变 (ATM) 途径并诱导细胞衰老。 产品来源： https://www.medchemexpress.cn/BRD4770.html 研究领域：Epigenetics 作用靶点：Histone Methyltransferase In Vitro: BRD4770 (0-20 µM; 72 hours; PANC-1 cells) treatment reduces the number of cells after 72 h. BRD4770 (2.5-5 µM; 24 hours; PANC-1 cells) treatment decreases H3K9 trimethylation level by 23% in PANC-1 cells. BRD4770 induces a senescent phenotype in a pancreatic cancer cell line. BRD4770 also inhibits both anchorage-dependent and -independent cell proliferation and induces G2/M cell-cycle arrest. BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway without inducing DNA damage, while the ataxia telangiectasia and Rad3-related protein (ATR) pathway is not affected. BRD4770 also induces increased levels of lysine acetylation in cells without inhibiting histone deacetylases. 相关产品：Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Reprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Membrane Protein-targeted Compound Library | Anti-Hematopathy Compound Library | Bioactive Compound Library Max | GSK126 | Pinometostat | Tazemetostat | GSK3326595 | 3-Deazaneplanocin A hydrochloride | GSK343 | GSK3368715 dihydrochloride | BIX-01294 | EPZ015666 | EZM0414 TFA | Chaetocin | EED226 | MS023 | UNC1999 | Onametostat | OICR-9429 | EZM 2302 | MRTX-1719 | UNC0642 | UNC0379 | SGC0946 | UNC0224 | GSK591 | Sinefungin | EPZ004777 | MS177 | UNC0638 | A-366 | TP-064 | NSC 663284 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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