PTP1B-IN-2 | MedChemExpress (MCE)

PTP1B-IN-2 产品活性：PTP1B-IN-2是有效地蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂，IC50值为50 nM。 产品来源： https://www.medchemexpress.cn/PTP1B-IN-2.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Phosphatase In Vitro: PTP1B-IN-2 displays more than 40-fold selectivity for PTP1B over SHP-2 and LAR and 15-fold higher selectivity for PTP1B over the highly homologous TCPTP. PTP1B-IN-2 extends deep into the active site pocket, forming several hydrogen bonds and hydrophobic interactions with key residues of the catalytic site. The binding characteristics between PTP1B domain and ligand shows that PTP1B-IN-2 is an ABC type inhibitor which not only interacted with catalytic site but also B site and C site. PTP1B-IN-2 greatly enhances insulin-mediated IRβ phosphorylation at concentrations of 15 μM and 30 μM. Insulin-stimulated glucose uptake is also significantly increased in L6 myotubes treated with PTP1B-IN-2, and this increase is 16.0%, 19.0% and 38.1% at 5, 10 and 20 μM, respectively . 相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Phosphatase Inhibitor Library | Anti-Obesity Compound Library | Metabolic Enzyme Compound Library | Bioactive Compound Library Max | Cyclosporin A | Tacrolimus | SHP099 | Calyculin A | β-Glycerophosphate disodium salt pentahydrate | Okadaic acid | Salubrinal | Sodium orthovanadate | Ebselen | Batoprotafib | L-Ascorbic acid 2-phosphate trisodium | Suramin sodium salt | Osunprotafib | RMC-4550 | TPI-1 | GSK 2830371 | Sodium metatungstate | DT-061 | SF1670 | Vociprotafib | NSC 663284 | Idoxuridine | D-erythro-Sphingosine | MSI-1436 lactate | BCI | LB-100 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

PTP1B-IN-2 | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供，如您想了解更多关于PTP1B-IN-2 | MedChemExpress (MCE)报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途