EPI-001 | MedChemExpress (MCE)

EPI-001 产品活性：EPI-001 是一种选择性雄激素受体 (AR) 的抑制剂，靶向 AR 的反式激活单元 5 (Tau-5)。EPI-001 可抑制 AR 氨基末端结构域 (NTD) 的反式激活，IC50 值约为 6 μM。EPI-001 也是一种选择性的 PPARγ 调节剂。EPI-001 对去势抵抗性前列腺癌具有活性。 产品来源： https://www.medchemexpress.cn/epi-001.html 研究领域：Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage | Apoptosis 作用靶点：Androgen Receptor | PPAR | Apoptosis In Vitro: EPI-001 (5-100 μM; 7 d) inhibits PCa/CRPC cell growth in a dose-dependent manner.? EPI-001 (50 μM) inhibits endogenous AR mRNA and protein expression in PCa and CRPC cell lines.? EPI-001 (50 μM) inhibits transcriptional activity of both AR TAU1 and TAU5. In Vivo: EPI-00 (20 mg/kg; i.v. every 5 d for 25 d) inhibits the growth of tumors and has no general toxicity in vivo.? EPI-00 (50 mg/kg; i.v.) blocks the androgen-axis and inhibits androgen-dependent tumor growth. 相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Neurodegenerative Disease-related Compound Library | Transcription Factor-Targeted Library | Anti-Prostate Cancer Compound Library | Nuclear Receptor Compound Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Anti-Drug-Resistant Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Retinoic acid | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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